Modulating the metabolic response to injury and infection

Modulating the metabolic response to injury and infection.

The host metabolic response to injury, be it defined as traumatic or infectious in nature, is characterized by diverse alterations in substrate turnover at the systemic and tissue levels (Lowry, 1986; Goldstein & Elwyn, 1989). Numerous studies attest to the extent of altered metabolic processes in injured and septic patient populations. For example, the isotopically determined rates of turnover...

Manipulating the metabolic response to injury.

In this short review we will concentrate on just one of the features of the metabolic response to injury (classified as accidental trauma, injury or sepsis) which are collectively known as the 'flow' phase. These include an increase in energy expenditure (hypermetabolism), changes in substrate utilisation (insulin resistance) and the focus of this chapter muscle wasting or catabolism. It is rec...

Metabolic response to starvation, injury and sepsis

Metabolic response to injury and role of anabolic hormones.

PURPOSE OF REVIEW To provide a short review of the literature describing the hypermetabolic response to injury and potential treatments. Associated findings include changes in inflammatory mediators and secreted hormones. RECENT FINDINGS Treatments should be aimed at decreasing the response and potentially the use of anabolic agents. Of note, recent interest in the hyperglycemic response to i...

Systemic Response to Injury and Metabolic Support: Introduction

1. Systemic inflammation is characterized by exaggerated immune responses to either a sterile or infectious process. The cause of inflammatory activation needs to be addressed to resolve the dysregulated immune state. 2. An understanding of the signaling mechanisms and pathways underlying systemic inflammation can help guide therapeutic interventions in injured and/or septic patients. 3. Manage...